Symptoms of Angiosarcomas
Identifying Angiosarcoma symptoms is difficult since there are few obvious symptoms until the cancer is extremely advanced and there are few symptoms that directly indicate the presence of tumor.It may take years for the angiosarcoma to develop and once it does it can affect many organs and systems of the body. The signs and symptoms of Angiosarcoma differ according to the location of the tumor.
A history of exposure to carcinogens such as vinyl chloride, radiation, or other chemicals is important to learn about during diagnosis so that symptoms msy be explored more deeply. These carcinogens begin the damage at the cellular level and it may take many years before the tumors appear.
A series of cellular growth disorders occur at the cellular level. These underpin much of the subsequent course in Angiosarcoma. A group of cells display uncontrolled growth and division beyond the normal limits and this can lead to intrusion on and destruction of adjacent tissues. The lymph or blood systems of the body can spread these cancer cells to other locations.
One type of Angiosarcoma is a Hemangiosarcoma which is a tumor in which blood vessels grow directly into the tumor. This can lead to symptoms of blood disorders. Uncontrolled growth and division of blood cells can cause bleeding and deficiency of platelets with small blood clots developing and blocking small blood vessels. The depletion of platelets and clotting factors then leads to issues of excessive bleeding. Anemia, one of the more common blood disorders, occurs when the level of healthy red blood cells in the body becomes too low. Health problems may result because the red blood cells carry oxygen to the body’s tissues. Fatigue and stress of body organs may result from the anemia.
Diagnosis of angiosarcomas that have advanced into the bone, skin or surrounding tissues becomes easier. Fatigue, reduced quantity of red blood cells, anemia, lumps or swelling under the skin, lesions, pain in the bones, dull aches and stabbing pains are symptoms that may be experienced. Diagnosis of internal Angiosarcomas are difficult but the tumors grow quickly. When the tumor has developed enough to display symptoms, treatment is usually ineffective.
Angiosarcomas arising at different sites and in different organs have some distinct features.
- Skin: People with Angiosarcoma of the skin frequently develop large, unmistakable lesions at the site of the tumor, which makes diagnosis much easier.The symptoms include enlarged bruises, nodules that are blue-black and ulcerations that do not heal. Pain at the site of the tumor is a frequent complain and there is often a significant discharge of blood lymph or other fluids.
- Bone: Angiosarcoma of the bone can weaken the bone making it susceptible to breaking. The tumors may grow on multiple bones of the same extremity. Tenderness at the affected site as well as pain and swelling may be symptoms.
- Liver: Liver Angiosarcoma is usually asymptomatic in the early stage. As the disease progresses hepatic dysfunctions appear as well as increasing loss of appetite, weight loss, and jaundice. The person may experience pain in the upper quadrant.
- Soft Tissue: Abdominal Angiosarcoma may rapidly grow to a large size in the abdomen before being detected. Hemorrhage, anemia and gastrointestinal bleeding are some of the symptoms that may occur. The adjacent lymph nodes may be enlarged.
Dr. Diane Simeone of the University of Michigan Comprehensive Cancer Center’s Multidisciplinary Pancreatic Cancer Program discusses the symptoms of pancreatic cancer.
